Browsing by keyword "ADP Ribose Transferases; Adenosine Diphosphate Ribose; Animals; Antigens, Differentiation, T-Lymphocyte; Catalysis; Cell Division; Cell Line; Histocompatibility Antigens; Linkage (Genetics); *Membrane Glycoproteins; Mice; NAD; Precipitin Tests; Rats; Recombinant Fusion Proteins; Spodoptera; T-Lymphocytes"

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    • Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity
      Bortell, Rita; Rigby, Mark R.; Stevens, Linda A.; Moss, Joel; Kanaitsuka, Toshihiro; Mordes, John P.; Greiner, Dale L.; Rossini, Aldo A. (1997-01-01)
      We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-ribose was attached to arginine residues on proteins. We also observed that the NAD+ concentration in culture medium correlates inversely with the proliferation of rat RT6+ T cells. The data suggest that lymphocyte surface ADP-ribosyltransferases could be involved in signaling and immunoregulatory processes.