• Catenin' on to nucleic acid sensing

      Rathinam, Vijay A.K.; Sharma, Shrutie; Fitzgerald, Katherine A. (2010-05-21)
      Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.