• Arteriovenous fistula masquerading as valvular heart disease

      Cantelmo, Nancy L.; Alpert, Joseph S.; Cutler, Bruce S.; Neuschatz, Joel S.; Romero, Luis; Ockene, Ira S. (1981-05-15)
    • Pulmonary artery hypertension in severe aortic stenosis: incidence and mechanism

      Silver, Kevin; Aurigemma, Gerard P.; Krendel, Steven; Barry, Nicole; Ockene, Ira S.; Alpert, Joseph S. (1993-01-01)
      We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH (pulmonary artery systolic pressure > 50 mm Hg); group 2 comprised 32 patients (71%) without PAH. Group 1 patients had a higher incidence of congestive heart failure, a lower left ventricular ejection fraction and cardiac index, and more mitral regurgitation as compared with group 2 patients. Of the 13 group 1 patients, 8 had a transpulmonary gradient (pulmonary artery mean pressure--pulmonary capillary wedge pressure) > or = 10 mm Hg, consistent with reactive PAH. We conclude that PAH frequently accompanies aortic stenosis and is often reactive.
    • Relation of left atrial size to pulmonary capillary wedge pressure in severe mitral regurgitation

      Pape, Linda A.; Price, Janet M.; Alpert, Joseph S.; Ockene, Ira S.; Weiner, Bonnie H. (1991-01-01)
      4,071 consecutive cardiac catheterizations were reviewed retrospectively to obtain 56 cases of pure mitral regurgitation among whom chest X-ray, electrocardiography and echocardiography had been performed within 10 days of catheterization. Mitral regurgitation was mild to moderate (1-2+) in 7 of the 56 cases while 49 had more severe regurgitation (3-4+). Left atrial size as measured by echocardiography was found to be enlarged in all but 2 cases. A positive correlation between left atrial size and severity of mitral regurgitation, irrespective of the height of the pulmonary capillary wedge pressure V wave was demonstrated. There was no demonstrable, predictive relationship between left atrial size and pulmonary capillary wedge pressure or electrocardiographic or chest X-ray findings. We conclude that knowledge of left atrial size is predictive of the severity of mitral regurgitation; however, it is not possible to predict the pulmonary capillary wedge pressure or height of the V waves based on a knowledge of left atrial dilatation in patients with pure mitral regurgitation.