Browsing by UMass Chan Affiliation "The Department of Pathology and Program in Immunology and Virology"
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Evolution of the CD8 T-cell repertoire during infectionsCD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.