Browsing by keyword "Thromboxanes"

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    • Selective thromboxane inhibition: a new approach to antiplatelet therapy
      Fisher, Marc; Weiner, Bonnie H.; Ockene, Ira S.; Hoogasian, James S.; Natale, Anita M.; Arsenault, John R.; Johnson, Mark H.; Levine, Peter H. (1984-09-01)
      Antiplatelet drugs as exemplified by aspirin are used frequently to prevent stroke. Aspirin inhibits the formation of both the potent platelet aggregator, thromboxane A2 and the potent anti-aggregator, prostacyclin. Another approach to the inhibition of platelet aggregation might involve selective suppression of thromboxane formation. We report our experience in swine with UK-38,485, a drug which selectively inhibits thromboxane formation. The rationale and potential uses of UK-38,485 in the in vivo prevention of platelet aggregation and for the therapy of cerebrovascular disease are discussed.