Browsing by keyword "MatErnal BLood IS Source to Accurately diagnose fetal aneuploidy (MELISSA) Study Group"
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PFRED: A computational platform for siRNA and antisense oligonucleotides design [preprint]PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides that target a specific gene of interest. Moreover, the tool facilitates the incorporation of various design criteria that have been shown to be important for stability and potency. PFRED has been made available as an open-source project so the code can be easily modified to address the future needs of the oligonucleotide research community. A compiled version is available for downloading at https://github.com/pfred/pfred-gui/releases as a java Jar file. The source code and the links for downloading the precompiled version can be found at https://github.com/pfred.
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Usability Testing Driven Redesign of Dataverse, an Open Source Data RepositoryPurpose: This study focuses on improvements in the usability of the Dataverse data repository open source software over the course of development of the latest version, 4.0, through iterative usability testing. Subjects:Thirty current international users of Dataverse comprised of researchers, librarians, and data archivists. Method: Users were selected to participate after either volunteering or being recommended by a member of the Dataverse development team. Users participated either in person or remotely (via Skype, Google Hangout or join.me) and sessions lasted for around 45 minutes. Each session involved a user completing specific tasks in Dataverse 4.0 to validate design decisions made for workflows. Each session was recorded with Morae software in order for the data to be later analyzed. Qualitative and quantitative data were collected through observation and surveys. The System Usability Scale was used as the postsession questionnaire as a way to track the perceived usability of Dataverse 4.0 as it was developed. To identify patterns in workflow issues, affinity diagrams were used to determine which usability issues happened most frequently and when workflows were interrupted. Results: This study began in December of 2013 and concluded in February 2015 lasted throughout the development of Dataverse 4.0 therefore results varied depending on what piece of functionality or feature was being developed at the time. With iterative usability testing, the taxonomy for Dataverse 4.0 was able to come straight from users not understanding labels that had been used and suggesting labels that were more logical to them, ways to provide users with multiple entry points to editing datasets was added based off user feedback, and faceted navigation for searching dataverses, datasets, and files was improved to allow users to narrow down to only one type easily. Conclusion: Overall, Dataverse 4.0 was able to quickly be tested and designs were able to be validated when they were developed rather than waiting months for users to interact with them. Most importantly, the Dataverse development team was able to release a product that had already been through extensive user review therefore eliminating potentially large issues that could or would impact a user being able to find or add data to Dataverse.

