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    Date Issued2022 (1)2020 (1)Author
    Roubil, John G. (2)
    Babak, Movahedi (1)Barry, Curtis T. (1)Bledsoe, Jacob R. (1)Bludevich, Bryce M. (1)View MoreUMass Chan AffiliationDepartment of Medicine (1)Department of Medicine, Division of Gastroenterology (1)Department of Pathology (1)Department of Radiology (1)Department of Surgery, Transplant Division (1)View MoreDocument TypeJournal Article (2)KeywordAllocation (1)BI-RADS 3 (1)BI-RADS criteria (1)breast cancer (1)Complications (1)View MoreJournalBiomedical journal of scientific and technical research (1)Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (1)

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    Value of BI-RADS 3 Audits

    Roychowdhury, Prithwijit; Vijayaraghavan, Gopal; Roubil, John G.; Williams, Imani M.; Siddiqui, Efaza; Vedantham, Srinivasan (2022-02-14)
    Objectives: BI-RADS 3 is an established assessment category in which the probability of malignancy is equal to or less than 2%. However, monitoring adherence to imaging criteria can be challenging and there are few established benchmarks for auditing BI-RADS 3 assignments. In this study, we explore some parameters that could serve as useful tools for quality control and clinical practice management. Materials and Methods: This retrospective study covered a 4-year period (Jan 2014-Dec 2017) and included all women over 40 years who were recalled from a screening exam and had an initial assignment of BI-RADS 3 (probably benign) category after diagnostic workup. A follow-up period of 2 years following the assignment of BI-RADS 3 was used for quantitative quality control metrics. Results: Among 135,765 screening exams, 13,453 were recalled and 1,037 BI-RADS 3 cases met inclusion criteria. The follow-up rate at 24 months was 86.7%. The upgrade rate was 7.4% (77/1,037) [CI: 5.9-9.2%] and the PPV3 was 33.8% (26/77) [CI: 23.4-45.5%]. The cancer yield was 2.51% (26/1,037) [CI: 1.64-3.65%] and did not differ (p=0. 243) from the 2% probability of malignancy. The initial BI-RADS3 per screening exam and per recall from screening were 0.76% (1,037/135,765) [CI: 0.72-0.81%] and 7.7% (1,037/13,453) [CI: 7.26-8.17%], respectively. Conclusion: Regular audit of BIRADS 3 metrics has the potential to provide additional insights for clinical practice management. Data from varied clinical settings with input from an expert committee could help establish benchmarks for these metrics.
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    Resolution of Severe Graft Steatosis Before Living-Donor Liver Transplant After 86 Pounds of Weight Loss

    Roubil, John G.; Martins, Paulo N.A.; Babak, Movahedi; Bledsoe, Jacob R.; Bludevich, Bryce M.; Barry, Curtis T.; Bozorgzadeh, Adel (2020-08-07)
    Living-donor liver transplant allows for expedited transplant, with outcomes shown to be superior compared with deceased-donor liver transplant due to earlier intervention, with reduced hospital costs. However, they only comprise about 5% of liver transplants nationally. This is due to a limited pool of willing donors and donor exclusions for medical and psycho-social reasons. The leading reason for why potential living liver donors are not eligible is nonalcoholic fatty liver disease. Donor hepatic steatosis limits the number of potential living-donor liver transplants because it is associated with perioperative complications in both donors and recipients. Here, we describe a 37-year-old male potential living donor who presented with hepatic steatosis based on preoperative imaging. Over a 1-year period, he was able to completely reverse his hepatic steatosis by losing about 86 pounds (from 279 to 193 pounds), reducing his body mass index from 40 to 28.55 kg/m(2). Computed tomography and biopsy results after his weight loss showed that he had no hepatic steatosis, allowing him to become a living donor for his mother. Postoperative periods for both the donor and recipient were uncomplicated. This case suggests that the pool of living liver donors could be expanded through dietary and behavior modifications, thus increasing the number of potential living donors and providing potential recipients with more transplant options. Enlarging this pool of donors will also improve transplant outcomes for donors and recipients and lower overall health care costs compared with deceased-donor liver transplant.
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