As people around the world experience a devastating pandemic, it is critical that policy-makers consider the methodological and measurement issues that might be associated with coronavirus disease 2019 (COVID-19) public health indicators. This commentary uses four primary variables to illustrate measurement and methodological issues that can complicate comparisons between jurisdictions. Jurisdiction refers to a variety of geographic areas, such as a country, a state, or a province/territory. These variables play a critical role in determining how we understand the trajectory of disease spread. These variables also contribute to our understanding of prevention strategies and their associated efficacy, reflecting the impact of COVID-19 on hospitals. It is critical for public health stakeholders and the public to recognize that these four simple variables can vary substantially across jurisdictions.