Intracellular signaling by the erythropoietin receptor
Lodish, Harvey F. Saghi, Ghaffari Socolovsky, Merav Wei, Tong Jing, Zhang
Citations
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Publication Date
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
The erythropoietin receptor (EPOR) is crucial for promoting the survival, proliferation, and differentiation of mammalian erythroid progenitors [1]. Differentiation from colony-forming units-erythroid (CFU-E) to late basophilic erythroblasts is highly EPO dependent, whereas differentiation beyond this stage is no longer dependent on EPO, but requires adhesion of the cells to a fibronectin matrix, through α4β1 integrin [2].
Source
Lodish, H.F., Ghaffari, S., Socolovsky, M., Tong, W., Zhang, J. (2009). Intracellular signaling by the erythropoietin receptor. In: Elliott, S.G., Foote, M.A., Molineux, G. (eds) Erythropoietins, Erythropoietic Factors, and Erythropoiesis. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8698-6_10