Gastrointestinal (GI) endoscopic procedures are central and critical components in diagnosing, managing and monitoring numerous pediatric conditions affecting the GI tract (1). Undergoing GI endoscopy can be uncomfortable for young patients, and typically requires sedation. Consequently, ensuring the safe and effective undertaking of procedures in children of all ages is important. In recent years, there have been numerous advances in methods and in technology that are now regular features of pediatric GI endoscopy. This Research Topic aimed to draw together a series of reports focusing on various relevant and topical aspects of endoscopy and sedation in children and adolescents.