Results of treatment of fifty-six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: a report from The Intergroup Rhabdomyosarcoma Study-IV, 1991-1997
Raney, R Beverly. Stoner, Julie A. Walterhouse, David O. Andrassy, Richard J. Donaldson, Sarah S. Laurie, Fran Meyer, William H. Qualman, Stephen J. Crist, William M.
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Abstract
BACKGROUND: We reviewed 56 IRS-IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum/pelvis to assess outcome and prognostic factors, including the value of initially excising > or=50% of the tumor (debulking) before chemotherapy.
METHODS: Patients had embryonal RMS [N=38], alveolar RMS [N = 7], RMS not otherwise specified [NOS, N = 7], or undifferentiated sarcoma [N = 4]. Fifteen patients were debulked; 41 patients were biopsied. All received VAC; most received radiotherapy.
RESULTS: Estimated 5-year failure-free survival [FFS] and overall survival rates were 70 and 75%, respectively. FFS rates were better for patients /undifferentiated sarcoma. After adjusting for age and histological differences, FFS was better for patients whose tumor was debulked prior to beginning therapy [P = 0.02].
CONCLUSIONS: These results are superior to those of previous protocols for patients with RMS of the retroperitoneum/pelvis. Initial excision of > or=50% of the tumor may be associated with increased FFS.
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Pediatr Blood Cancer. 2004 Jun;42(7):618-25. Link to article on publisher's site