Evolution of the CD8 T-cell repertoire during infections
Lin, Meei-Yun ; Selin, Liisa K. ; Welsh, Raymond M.
Lin, Meei-Yun
Selin, Liisa K.
Welsh, Raymond M.
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Faculty Advisor
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2000-09-01
Keywords
Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Flow Cytometry; Herpesvirus 4, Human; Interferon Type II; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocyte Subsets; Virus Latency
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Medicine and Health Sciences
Life Sciences
Medicine and Health Sciences
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Abstract
CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.
Source
Microbes Infect. 2000 Jul;2(9):1025-39.
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PubMed ID
10967283