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Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung

Chen, Hong D.
Fraire, Armando E.
Joris, Isabelle
Brehm, Michael A.
Welsh, Raymond M.
Selin, Liisa K.
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Abstract

A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.

Source

Nat Immunol. 2001 Nov;2(11):1067-76. Link to article on publisher's site

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DOI
10.1038/ni727
PubMed ID
11668342
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