Purpose: Partial volume effects (PVE) remain a major challenge in quantitative single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging, often compromising both accuracy and reproducibility. While numerous Partial Volume Correction (PVC) methods have been proposed, their clinical translation is still limited. This review provides a clinically oriented evaluation of PVC methods with a particular focus on state-of-the-art applications in neurology, cardiovascular imaging, oncology, and radiopharmaceutical therapy dosimetry, highlighting where these techniques offer the greatest added value. In addition, we outline which PVC techniques have the potential to be used in clinical practice and which remain primarily suited for research purposes, along with their suitability in each of the above-mentioned clinical domains. Finally, this review addresses the central question of whether PVC is essential in clinical practice or whether its impact is context dependent.

Methods: This review categorizes PVC approaches into three partially overlapping classes: reconstruction-based, post-reconstruction-based, and AI-driven or hybrid methods. Each class is further divided into anatomical and non-anatomical subcategories. We systematically compare their clinical applicability across key dimensions: quantitative accuracy, lesion detectability, robustness to noise and artifacts, anatomical dependence, generalizability across scanners and tracers, and clinical readiness.

Results: PVC techniques often improve quantitative accuracy in small structures and in regions affected by spill-over from adjacent high-uptake tissues. However, these benefits can come at the cost of increased noise or edge artifacts, which may limit their robustness for routine clinical use. Post-reconstruction methods are sensitive to segmentation errors, while AI-driven models, despite their promise, require further validation using clinical benchmarks, comparison to ground truth, and testing on diverse datasets. Issues, such as generalizability and interpretability remain significant barriers.

Conclusion: This review emphasizes the importance of application-tailored PVC protocols for reliable quantitative imaging in neurology, cardiology, oncology, and radiopharmaceutical therapy dosimetry. Not all PVC methods are beneficial; some may even impair interpretation in certain contexts. We provide a practical overview of which PVC approaches are most beneficial for each clinical scenario, aiming to guide both researchers and clinicians in selecting appropriate techniques for future studies and routine practice, and also outline key areas requiring further development for broader integration into research and clinical workflows.