Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus
Saikh, Kamal U. Tamura, Manabu Kuwano, Koichi Dai, Li-Chen C. West, Kim Ennis, Francis A.
Saikh, Kamal U.
Tamura, Manabu
Kuwano, Koichi
Dai, Li-Chen C.
West, Kim
Ennis, Francis A.
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Journal Article
Publication Date
1993-01-01
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Abstract
We reported previously that adoptive immunization with an influenza A virus NS1-specific H-2Ld-restricted, cross-reactive, CTL clone A-11 established by stimulation with A/PR/8/34 virus (H1N1) reduced lung virus titers in mice challenged with virus in vivo (Virology 178:174-179, 1990). Using a set of recombinant vaccinia virus constructs containing truncated portions of the NS gene we have localized this cross-protective CTL epitope to the N-terminal region of the NS1 protein. This region of NS1 is active in inducing CD8+ CTL in vivo because virus-stimulated BALB/c immune spleen cells in bulk cultures also recognized the N-terminal region of the NS1 protein.
Source
Viral Immunol. 1993 Winter;6(4):229-36. Link to article on publisher's site
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DOI
10.1089/vim.1993.6.229
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PubMed ID
7513168