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Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans [preprint]
Shipley, Frederick B. ; Clark, Christopher M. ; Alkema, Mark J ; Leifer, Andrew M.
Shipley, Frederick B.
Clark, Christopher M.
Alkema, Mark J
Leifer, Andrew M.
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Student Authors
Christopher M. Clark
Faculty Advisor
Academic Program
Neuroscience
UMass Chan Affiliations
Document Type
Preprint
Publication Date
2014-04-02
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Abstract
A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observes behavior in freely moving C. elegans. We use the instrument to directly observe the relation between sensory stimuli, interneuron activity and locomotion in the mechanosensory circuit. Now published as: Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028
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bioRxiv 000943; doi: https://doi.org/10.1101/000943. Link to preprint on bioRxiv service.
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DOI
10.1101/000943
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Now published in Front Neural Circuits 8:28, doi:10.3389/fncir.2014.00028
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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC 4.0 International license.