Is this the end for ranitidine? NDMA presence continues to confound
Wagner, Jennifer A. ; Dinh, Jean C. ; Lightdale, Jenifer R. ; Gold, Benjamin D. ; Colombo, Jennifer M.
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Abstract
N-nitrosodimethylamine (NDMA), a probable human carcinogen, was discovered decades ago, although elevated levels in several widely used drugs were detected only recently. Several medications that are now known to contain NDMA have remained available, whereas ranitidine has been completely withdrawn from the market. In the following paper, we discuss the overview of events that led to the withdrawal of ranitidine and compare evidence and subsequent regulatory response of other medications also containing NDMA.
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Wagner JA, Dinh JC, Lightdale JR, Gold BD, Colombo JM. Is this the end for ranitidine? NDMA presence continues to confound. Clin Transl Sci. 2021 Jul;14(4):1197-1200. doi: 10.1111/cts.12995. Epub 2021 May 2. PMID: 33934515; PMCID: PMC8301580. Link to article on publisher's site