Issue preface: This slim issue of thirteen articles was specifically designed with the needs of the General Pediatrician in mind. The list of topics covers a broad scope of clinical issues that are common among adolescent patients, particularly adolescents who are sexually active. Many pediatricians feel poorly equipped to address sexual matters in teens either because they do not have updated knowledge about them or because the issues are complicated and take more time than usually scheduled in a busy practice. This issue will help pediatricians feel more confident caring for their adolescent patients. All the authors have made a concerted effort to provide a concise review of the topic assigned to them coupled with practical suggestions for the clinician to consider.