Immune escape by Epstein-Barr virus associated malignancies
Munz, Christian ; Moormann, Ann M.
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UMass Chan Affiliations
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Keywords
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cancer Vaccines
Epstein-Barr Virus Infections
HIV Infections
Herpesvirus 4, Human
Humans
Malaria, Falciparum
Neoplasms
Tumor Escape
Virus Activation
Virus Latency
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Pediatrics
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Abstract
Persistent Epstein-Barr virus (EBV) infection remains asymptomatic in the majority of virus carriers, despite the potent growth transforming potential of this virus. The increased frequency of EBV associated B cell lymphomas in immune compromised individuals suggests that tumor-free chronic infection with this virus is in part due to immune control. Here we discuss the evidence that loss of selective components of EBV specific immunity might contribute to EBV associated malignancies, like nasopharyngeal carcinoma, Burkitt's and Hodgkin's lymphoma, in otherwise immune competent patients. Furthermore, we discuss how current vaccine approaches against EBV might be able to target these selective deficiencies.
Source
Semin Cancer Biol. 2008 Dec;18(6):381-7. Epub 2008 Oct 19. Link to article on publisher's site