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A Sugar Rush for Innate Immunity

Orning, M. Pontus A.
; 
Flo, Trude H.
; 
Lien, Egil
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Authors
Orning, M. Pontus A.
Flo, Trude H.
Lien, Egil
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Faculty Advisor
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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal Article
Publication Date
2018-10-10
Keywords
Immunity
 Microbiology
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UMass Chan Faculty and Researcher Publications
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510543/
Abstract

Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-kappaB activation and identified the bacterial sugar ADP-Hep as its ligand.

Source

Orning P, Flo TH, Lien E. A Sugar Rush for Innate Immunity. Cell Host Microbe. 2018 Oct 10;24(4):461-463. doi: 10.1016/j.chom.2018.09.017. PMID: 30308148; PMCID: PMC6510543. Link to article on publisher's site

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DOI
10.1016/j.chom.2018.09.017
Permanent Link to this Item
https://hdl.handle.net/20.500.14038/35196
PubMed ID
30308148
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