Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
Mayasi, Yunis M Takhtani, Deepak Garg, Neeta
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Abstract
OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis.
METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed.
RESULTS: The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well.
CONCLUSION: LGI1 antibody-associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.
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Neurol Neuroimmunol Neuroinflamm. 2014 Dec 11;1(4):e51. doi: 10.1212/NXI.0000000000000051. eCollection 2014 Dec. Link to article on publisher's site