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Do iterative implant innovations translate to better outcomes? A comparison of three implant designs after uncemented total knee arthroplasty

Peresuh, Simbarashe J
Gilreath, Noah
Liu, Jonathan
Daher, Mohammad
Nalli, Sara
Patel, Aditya D
Arcand, Michel A
Most, Mathew J
Antoci, Valentin
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Abstract

BACKGROUND: Despite advancements in total knee arthroplasty (TKA) implant design, 20 % of patients remain dissatisfied. Implants have been developed to improve biomechanics and patient-reported outcomes, yet evidence suggests comparable long-term results between modern anatomic and traditional implants. This study evaluated whether newer implant designs provide meaningful and measurable clinical value.

METHODS: Retrospective chart review for primary TKA patients at a single institution (01/2016 - 05/2023). Patients were stratified based on uncemented implant design. Exclusion criteria: missing data, incomplete Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS) questionnaires, or follow-up under 12 months. Preoperative and 12-month postoperative KOOS scores for activities of daily living (ADL), PAIN, and quality of life (QoL), as well as Mental (MCS) and Physical Component Scores (PCS), were analyzed. The Kruskal-Wallis test was used for continuous variables, and -square/Fisher's exact tests for categorical data (P < 0.05).

RESULTS: Baseline characteristics and preoperative outcome scores were comparable across groups. ADL, PAIN, QoL, and KOOS (P = 0.883) scores were comparable between groups at 12 months. MCS score change from baseline to 12 months was significantly different (P = 0.02), though its clinical relevance remains uncertain.

CONCLUSION: Design modifications from the multi-radius trochlear groove for altered femoral geometry and 3D-printed porous surface for uncemented fixation were introduced to improve patellofemoral mechanics and implant integration, there was no significant translation to improved patient-reported outcomes in this study. These findings suggest that patient and procedure-specific factors may be influential in determining TKA outcomes more than implant design alone.

Source

Peresuh SJ, Gilreath N, Liu J, Daher M, Nalli S, Patel AD, Arcand MA, Most MJ, Antoci V. Do iterative implant innovations translate to better outcomes? A comparison of three implant designs after uncemented total knee arthroplasty. J Orthop. 2025 Dec 8;73:234-240. doi: 10.1016/j.jor.2025.12.004. PMID: 41503228; PMCID: PMC12771322.

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10.1016/j.jor.2025.12.004
PubMed ID
41503228
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© 2025 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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