Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy
Lee, Michael J
Lee, Michael J
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Student Authors
Faculty Advisor
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2015-03-05
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Abstract
Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.
Source
Mol Cell. 2015 Mar 5;57(5):763-4. doi: 10.1016/j.molcel.2015.02.030. Link to article on publisher's site
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DOI
10.1016/j.molcel.2015.02.030
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PubMed ID
25747655