Emergency medicine (EM) has a scientifically derived and commonly accepted description of the domain of its clinical practice. That document, “The Model of the Clinical Practice of Emergency Medicine” (EM Model), was developed through the collaboration of six organizations: the American Board of Emergency Medicine (ABEM), the administrative organization for the project, the American College of Emergency Physicians (ACEP), the Council of Emergency Medicine Residency Directors (CORD), the Emergency Medicine Residents' Association (EMRA), the Residency Review Committee for Emergency Medicine (RRC-EM), and the Society for Academic Emergency Medicine (SAEM)....This article provides a brief review of the original EM Model, along with the changes to the EM Model as recommended by the 2016 EM Model Review Task Force. Significant changes occurred with the 2016 review, including extensive revision of Category 17, Toxicologic Disorders. A summary of all 2016 changes and an update on current uses of the EM Model by the seven collaborating EM organizations are also included in this article.