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Bone marrow cells as the origin of stomach cancer

Stoicov, Calin
Li, Hanchen
Carlson, Jane E.
Houghton, JeanMarie
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Student Authors
Calin Stoicov
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Document Type
Journal Article
Publication Date
2006-03-25
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Abstract

Cells derived from bone marrow are pluripotent, with the ability to differentiate into multiple cell types. Environmental cues dictate differentiation decisions. It should not be surprising then, that abnormal cell environments lead to abnormal differentiation of these cells, and in some cases, malignant transformation. Identifying a role for bone marrow-derived cells in the initiation and progression of cancer allows a dramatic change in the way in which cancer is viewed. Identifying the cell responsible for initiating a tumor offers the exciting possibility of specifically targeting unique aspects of these cells and altering signaling properties for more effective therapeutic approaches.

Source

Future Oncol. 2005 Dec;1(6):851-62. Link to article on publisher's site

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DOI
10.2217/14796694.1.6.851
PubMed ID
16556065
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