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PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness

Roussos, Panos
Vaccarino, Flora M
Weng, Zhiping
Sestan, Nenad
Gerstein, Mark
Geschwind, Daniel H
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Journal Article
Publication Date
2025-12-17
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Abstract

Over the past decade, the PsychENCODE Consortium has transformed psychiatric genomics-from static maps of genetic risk to dynamic, cell-resolved models of the human brain-linking DNA sequence to neural circuitry and behavior and laying the foundation for precision approaches to mental illness.

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Roussos P, Vaccarino FM, Weng Z, Sestan N, Gerstein M, Geschwind DH. PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness. Neuron. 2025 Dec 17;113(24):4099-4102. doi: 10.1016/j.neuron.2025.11.027. PMID: 41412064.

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10.1016/j.neuron.2025.11.027
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41412064
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Published by Elsevier Inc.
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