Aneurysm permeability following coil embolization: packing density and coil distribution

Show simplified metadata
dc.contributor.authorChueh, Juyu
dc.contributor.authorVedantham, Srinivasan
dc.contributor.authorWakhloo, Ajay K.
dc.contributor.authorCarniato, Sarena L.
dc.contributor.authorPuri, Ajit S
dc.contributor.authorBzura, Conrad
dc.contributor.authorCoffin, Spencer
dc.contributor.authorBogdanov, Alexei A. Jr.
dc.contributor.authorGounis, Matthew J
dc.contributor.departmentDepartment of Radiology
dc.date2022-08-11T08:10:46.000
dc.date.accessioned2022-08-23T17:19:21Z
dc.date.available2022-08-23T17:19:21Z
dc.date.issued2014-07-16
dc.date.submitted2016-02-10
dc.description.abstractBACKGROUND: Rates of durable aneurysm occlusion following coil embolization vary widely, and a better understanding of coil mass mechanics is desired. The goal of this study is to evaluate the impact of packing density and coil uniformity on aneurysm permeability. METHODS: Aneurysm models were coiled using either Guglielmi detachable coils or Target coils. The permeability was assessed by taking the ratio of microspheres passing through the coil mass to those in the working fluid. Aneurysms containing coil masses were sectioned for image analysis to determine surface area fraction and coil uniformity. RESULTS: All aneurysms were coiled to a packing density of at least 27%. Packing density, surface area fraction of the dome and neck, and uniformity of the dome were significantly correlated (p < 0.05). Hence, multivariate principal components-based partial least squares regression models were used to predict permeability. Similar loading vectors were obtained for packing and uniformity measures. Coil mass permeability was modeled better with the inclusion of packing and uniformity measures of the dome (r(2)=0.73) than with packing density alone (r(2)=0.45). The analysis indicates the importance of including a uniformity measure for coil distribution in the dome along with packing measures. CONCLUSIONS: A densely packed aneurysm with a high degree of coil mass uniformity will reduce permeability.
dc.identifier.citation<p>J Neurointerv Surg. 2015 Sep;7(9):676-81. doi: 10.1136/neurintsurg-2014-011289. Epub 2014 Jul 16. <a href="http://dx.doi.org/10.1136/neurintsurg-2014-011289">Link to article on publisher's site</a></p>
dc.identifier.contextkey8123639
dc.identifier.doi10.1136/neurintsurg-2014-011289
dc.identifier.issn1759-8478 (Linking)
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/radiology_pubs/157
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1167&amp;context=radiology_pubs&amp;unstamped=1
dc.identifier.pmid25031179
dc.identifier.submissionpathradiology_pubs/157
dc.identifier.urihttps://hdl.handle.net/20.500.14038/48052
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25031179&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <a href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</a>
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.source.issue9
dc.source.journaltitleJournal of neurointerventional surgery
dc.source.pages676-81
dc.source.volume7
dc.subjectAneurysm
dc.subjectCoil
dc.subjectIntervention
dc.subjectCardiovascular Diseases
dc.subjectNervous System Diseases
dc.subjectRadiology
dc.subjectSurgery
dc.titleAneurysm permeability following coil embolization: packing density and coil distribution
dc.typeJournal Article
dspace.entity.typePublication
html.description.abstract<p>BACKGROUND: Rates of durable aneurysm occlusion following coil embolization vary widely, and a better understanding of coil mass mechanics is desired. The goal of this study is to evaluate the impact of packing density and coil uniformity on aneurysm permeability.</p> <p>METHODS: Aneurysm models were coiled using either Guglielmi detachable coils or Target coils. The permeability was assessed by taking the ratio of microspheres passing through the coil mass to those in the working fluid. Aneurysms containing coil masses were sectioned for image analysis to determine surface area fraction and coil uniformity.</p> <p>RESULTS: All aneurysms were coiled to a packing density of at least 27%. Packing density, surface area fraction of the dome and neck, and uniformity of the dome were significantly correlated (p < 0.05). Hence, multivariate principal components-based partial least squares regression models were used to predict permeability. Similar loading vectors were obtained for packing and uniformity measures. Coil mass permeability was modeled better with the inclusion of packing and uniformity measures of the dome (r(2)=0.73) than with packing density alone (r(2)=0.45). The analysis indicates the importance of including a uniformity measure for coil distribution in the dome along with packing measures.</p> <p>CONCLUSIONS: A densely packed aneurysm with a high degree of coil mass uniformity will reduce permeability.</p>
refterms.dateFOA2022-08-23T17:19:21Z
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
J_NeuroIntervent_Surg_2015_Chueh_676_81.pdf
Size:
667.01 KB
Format:
Adobe Portable Document Format
Download
Collections
Radiology Publications