Releasing the brakes on a chromatin-remodeling enzyme
Manning, Benjamin J. ; Peterson, Craig L.
Manning, Benjamin J.
Peterson, Craig L.
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2013-01-01
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Abstract
Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.
Source
Nat Struct Mol Biol. 2013 Jan;20(1):5-7. doi: 10.1038/nsmb.2482. Link to article on publisher's site
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DOI
10.1038/nsmb.2482
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PubMed ID
23288358