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Microglia phagocytic mechanisms: Development informing disease

Beiter, Rebecca M
Sheehan, Patrick W
Schafer, Dorothy P
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Journal Article
Publication Date
2024-04-16
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Abstract

Microglia are tissue-resident macrophages and professional phagocytes of the central nervous system (CNS). In development, microglia-mediated phagocytosis is important for sculpting the cellular architecture. This includes the engulfment of dead/dying cells, pruning extranumerary synapses and axons, and phagocytosing fragments of myelin sheaths. Intriguingly, these developmental phagocytic mechanisms by which microglia sculpt the CNS are now appreciated as important for eliminating synapses, myelin, and proteins during neurodegeneration. Here, we discuss parallels between neurodevelopment and neurodegeneration, which highlights how development is informing disease. We further discuss recent advances and challenges towards therapeutically targeting these phagocytic pathways and how we can leverage development to overcome these challenges.

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Beiter RM, Sheehan PW, Schafer DP. Microglia phagocytic mechanisms: Development informing disease. Curr Opin Neurobiol. 2024 Apr 16;86:102877. doi: 10.1016/j.conb.2024.102877. Epub ahead of print. PMID: 38631077.

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10.1016/j.conb.2024.102877
PubMed ID
38631077
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