Loading...
Thumbnail Image
Publication

Role of the MAPK/cJun NH2-Terminal Kinase signaling pathway in starvation-induced autophagy

Barutcu, Seda
Girnius, Nomeda
Vernia, Santiago
Davis, Roger J.
Embargo Expiration Date
Link to Full Text
Abstract

Autophagy is required for cellular homeostasis and can determine cell viability in response to stress. It is established that MTOR is a master regulator of starvation-induced macroautophagy/autophagy, but recent studies have also implicated an essential role for the MAPK8/cJun NH2-terminal kinase 1 signal transduction pathway. We found that MAPK8/JNK1 and MAPK9/JNK2 were not required for autophagy caused by starvation or MTOR inhibition in murine fibroblasts and epithelial cells. These data demonstrate that MAPK8/9 has no required role in starvation-induced autophagy. We conclude that the role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered.

Source

Autophagy. 2018 Jun 28. doi: 10.1080/15548627.2018.1466013. [Epub ahead of print] Link to article on publisher's site

Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1080/15548627.2018.1466013
PubMed ID
29950132
Other Identifiers
Notes
Funding and Acknowledgements
Corresponding Author
Related Resources
Related Resources
Repository Citation
Rights
Accepted author version. This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted. The moral rights of the named author(s) have been asserted.
Distribution License