Role of the MAPK/cJun NH2-Terminal Kinase signaling pathway in starvation-induced autophagy
Barutcu, Seda ; Girnius, Nomeda ; Vernia, Santiago ; Davis, Roger J.
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Abstract
Autophagy is required for cellular homeostasis and can determine cell viability in response to stress. It is established that MTOR is a master regulator of starvation-induced macroautophagy/autophagy, but recent studies have also implicated an essential role for the MAPK8/cJun NH2-terminal kinase 1 signal transduction pathway. We found that MAPK8/JNK1 and MAPK9/JNK2 were not required for autophagy caused by starvation or MTOR inhibition in murine fibroblasts and epithelial cells. These data demonstrate that MAPK8/9 has no required role in starvation-induced autophagy. We conclude that the role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered.
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Autophagy. 2018 Jun 28. doi: 10.1080/15548627.2018.1466013. [Epub ahead of print] Link to article on publisher's site