Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine
Yoshii, Tatsuyuki Geng, Yingying Peyton, Shelly Mercurio, Arthur M. Rotello, Vincent M.
Yoshii, Tatsuyuki
Geng, Yingying
Peyton, Shelly
Mercurio, Arthur M.
Rotello, Vincent M.
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2016-09-01
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Abstract
Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
Source
Drug Discov Today. 2016 Sep;21(9):1489-94. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Link to article on publisher's site
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DOI
10.1016/j.drudis.2016.05.011
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PubMed ID
27238384