Towards the reconstruction of central nervous system white matter using neural precursor cells
Mitome, Masato ; Low, Hoi Pang ; van den Pol, Anthony ; Nunnari, John J. ; Wolf, Merrill K. ; Billings-Gagliardi, Susan ; Schwartz, William J.
Mitome, Masato
Low, Hoi Pang
van den Pol, Anthony
Nunnari, John J.
Wolf, Merrill K.
Billings-Gagliardi, Susan
Schwartz, William J.
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Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2001-10-24
Keywords
Animals
Astrocytes
Axons
Cells, Cultured
Central Nervous System
Corpus Striatum
Embryo, Mammalian
Epidermal Growth Factor
Female
Injections, Intraventricular
Lateral Ventricles
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Neurologic Mutants
Myelin Basic Proteins
Myelin Sheath
Oligodendroglia
*Stem Cell Transplantation
Stem Cells
Life Sciences
Medicine and Health Sciences
Astrocytes
Axons
Cells, Cultured
Central Nervous System
Corpus Striatum
Embryo, Mammalian
Epidermal Growth Factor
Female
Injections, Intraventricular
Lateral Ventricles
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Neurologic Mutants
Myelin Basic Proteins
Myelin Sheath
Oligodendroglia
*Stem Cell Transplantation
Stem Cells
Life Sciences
Medicine and Health Sciences
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
Epidermal growth factor-responsive neural precursor cells were used as donor cells for transplantation into wild-type and myelin-deficient shiverer (shi) mice. The cells engrafted robustly within the CNS following intracerebroventricular and cisternal transplantation in neonatal mice. The cells adopted glial phenotypes, and some functioned as oligodendrocytes, producing myelin basic protein and morphologically normal internodal myelin sheaths. When individual shi mice received two transplants (on post-natal days 1 and 3), donor-derived cells disseminated widely and expressed myelin basic protein in central white matter tracts throughout the brain.
Source
Brain. 2001 Nov;124(Pt 11):2147-61.
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DOI
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PubMed ID
11673317