Chitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis

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dc.contributor.authorKumar, Nathella Pavan
dc.contributor.authorNancy, Arul
dc.contributor.authorViswanathan, Vijay
dc.contributor.authorSivakumar, Shanmugam
dc.contributor.authorThiruvengadam, Kannan
dc.contributor.authorAhamed, Shaik Fayaz
dc.contributor.authorHissar, Syed
dc.contributor.authorKornfeld, Hardy
dc.contributor.authorBabu, Subash
dc.contributor.departmentMedicineen_US
dc.date.accessioned2024-06-17T14:33:11Z
dc.date.available2024-06-17T14:33:11Z
dc.date.issued2023-02-06
dc.description.abstractIntroduction: Chitinase, Indoleamine 2,3-dioxygenesae-1 (IDO-1) and heme oxygenase-1 (HO-1) are candidate diagnostic biomarkers for tuberculosis (TB). Whether these immune markers could also serve as predictive biomarkers of unfavorable treatment outcomes in pulmonary TB (PTB) is not known. Methods: A cohort of newly diagnosed, sputum culture-positive adults with drug-sensitive PTB were recruited. Plasma chitinase protein, IDO protein and HO-1 levels measured before treatment initiation were compared between 68 cases with unfavorable outcomes (treatment failure, death, or recurrence) and 108 control individuals who had recurrence-free cure. Results: Plasma chitinase and IDO protein levels but not HO-1 levels were lower in cases compared to controls. The low chitinase and IDO protein levels were associated with increased risk of unfavourable outcomes in unadjusted and adjusted analyses. Receiver operating characteristic analysis revealed that chitinase and IDO proteins exhibited high sensitivity and specificity in differentiating cases vs controls as well as in differentiating treatment failure vs controls and recurrence vs controls, respectively. Classification and regression trees (CART) were used to determine threshold values for these two immune markers. Discussion: Our study revealed a plasma chitinase and IDO protein signature that may be used as a tool for predicting adverse treatment outcomes in PTB.en_US
dc.identifier.citationKumar NP, Nancy A, Viswanathan V, Sivakumar S, Thiruvengadam K, Ahamed SF, Hissar S, Kornfeld H, Babu S. Chitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosis. Front Immunol. 2023 Feb 6;14:1093640. doi: 10.3389/fimmu.2023.1093640. PMID: 36814914; PMCID: PMC9939892.en_US
dc.identifier.doi10.3389/fimmu.2023.1093640en_US
dc.identifier.eissn1664-3224
dc.identifier.journalFrontiers in immunology
dc.identifier.pmid36814914
dc.identifier.urihttps://hdl.handle.net/20.500.14038/53497
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.relation.urlhttps://doi.org/10.3389/fimmu.2023.1093640en_US
dc.rights© 2023 Kumar, Nancy, Viswanathan, Sivakumar, Thiruvengadam, Ahamed, Hissar, Kornfeld and Babu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.source.beginpage1093640
dc.source.countrySwitzerland
dc.source.endpage
dc.source.journaltitleFrontiers in immunology
dc.source.volume14
dc.subject3-dioxygenesae-1en_US
dc.subjectchitinaseen_US
dc.subjectheme oxygenase-1en_US
dc.subjectindoleamine 2en_US
dc.subjectpulmonary tuberculosis (PTB)en_US
dc.subjectunfavourable TB treatmenten_US
dc.titleChitinase and indoleamine 2, 3-dioxygenase are prognostic biomarkers for unfavorable treatment outcomes in pulmonary tuberculosisen_US
dc.typeJournal Articleen_US
dspace.entity.typePublication
refterms.dateFOA2024-06-17T14:33:13Z
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