In 2013, the Learning and Working During the Transition to Adulthood Rehabilitation Research & Training Center, UMass Chan Medical School, successfully conducted a state of the science conference, “Tools for System Transformation for Young Adults with Psychiatric Disabilities.” The conference was held at Georgetown University National Technical Assistance Center for Children’s Mental Health on September 24-25th, 2013. We had two goals for this conference. Our first goal was to share and discuss the current state of research knowledge regarding practice and policy supports for strong educational and employment outcomes in young adults (ages 18-30) with psychiatric disabilities. Our second goal was to engage all attendees in prioritizing the knowledge that future research should address, to guide these systems’ efforts, to better launch and support these young adults’ long-term careers. The proceedings herein include all conference papers and responses as well as final considerations for the future research directions in education, employment and policy and practice. For more information, please visit our website: https://umassmed.edu/TransitionsACR/publication/conferences/state_of_the_science_conference/