Neuronal death or dismemberment mediated by Sox14
Osterloh, Jeannette M. Freeman, Marc R.
Osterloh, Jeannette M.
Freeman, Marc R.
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Student Authors
Jeannette Osterloh
Faculty Advisor
Academic Program
Neuroscience
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2009-11-26
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Abstract
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
Source
Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site
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DOI
10.1038/nn1209-1479
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PubMed ID
19935724