Kinetic Mechanism of Nicotinamide N-Methyltransferase.
Loring, Heather S. Thompson, Paul R
Loring, Heather S.
Thompson, Paul R
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UMass Chan Affiliations
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Journal Article
Publication Date
2018-09-25
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Abstract
Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. Aberrantly increased NNMT activity results in the depletion of SAM, nicotinamide (NAM), and nicotinamide adenine dinucleotide (NAD
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Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10.
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DOI
10.1021/acs.biochem.8b00775
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PubMed ID
30148963