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New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

Miller, Andrew Todd
Berg, Leslie J.
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Student Authors
Andrew Todd Miller
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Academic Program
Immunology and Virology
Document Type
Journal Article
Publication Date
2002-04-26
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Abstract

The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.

Source

Curr Opin Immunol. 2002 Jun;14(3):331-40.

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DOI
10.1016/S0952-7915(02)00345-X
PubMed ID
11973131
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