New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
Miller, Andrew Todd ; Berg, Leslie J.
Miller, Andrew Todd
Berg, Leslie J.
Citations
Altmetric:
Authors
Student Authors
Andrew Todd Miller
Faculty Advisor
Academic Program
Immunology and Virology
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2002-04-26
Keywords
Subject Area
Collections
Embargo Expiration Date
Link to Full Text
Abstract
The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.
Source
Curr Opin Immunol. 2002 Jun;14(3):331-40.
Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1016/S0952-7915(02)00345-X
Permanent Link to this Item
PubMed ID
11973131