Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity
Bortell, Rita ; Rigby, Mark R. ; Stevens, Linda A. ; Moss, Joel ; Kanaitsuka, Toshihiro ; Mordes, John P. ; Greiner, Dale L. ; Rossini, Aldo A.
Bortell, Rita
Rigby, Mark R.
Stevens, Linda A.
Moss, Joel
Kanaitsuka, Toshihiro
Mordes, John P.
Greiner, Dale L.
Rossini, Aldo A.
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Journal Article
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1997-01-01
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Abstract
We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-ribose was attached to arginine residues on proteins. We also observed that the NAD+ concentration in culture medium correlates inversely with the proliferation of rat RT6+ T cells. The data suggest that lymphocyte surface ADP-ribosyltransferases could be involved in signaling and immunoregulatory processes.
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Adv Exp Med Biol. 1997;419:169-73.
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PubMed ID
9193650