As “the scientific study of methods to promote the systematic uptake of research findings and other evidence-based practices into routine practice,” implementation science (IS) offers the potential to translate effective innovations in policing across agencies and local contexts with fidelity and sustainability in support of a commitment to evidence-based policing (EBP). Despite this potential, and its widespread use in adjacent fields facing similar challenges, implementation science remains almost completely unstudied and unutilized in police settings. To fill these gaps in research and practice, this paper provides an orientation to IS for police researchers and practitioners. It recounts EBP’s historical roots in an evidence-based approach to health care, demonstrates the commonalities that make IS as natural to policing as medicine, and surveys the existing literature on the employment of IS in policing. It adapts a conceptual model of IS to policing, presents two well-developed frameworks, and introduces three types of hybrid implementation/effectiveness trials suitable for use in dynamic police settings. It then provides illustrative cases in policing where the use of IS would be apt, and highlights the importance of the de-implementation of substandard or problematic practices as a key but often overlooked aspect of IS. It concludes by discussing how police practices that fully embrace evidence will nonetheless be guided by contestable values and norms, and how IS provides a way to address this concern. The paper provides research and practice agendas for integrating IS into EBP as police seek to adopt evidence-informed practices that deliver public safety, respect rights, and increase community satisfaction and trust.