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Sweat testing infants detected by cystic fibrosis newborn screening

Parad, Richard B.
Comeau, Anne Marie
Dorkin, Henry L.
Dovey, Mark
Gerstle, Robert
Martin, Thomas
O'Sullivan, Brian P.
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Abstract

OBJECTIVE: Describe and define limitations of early pilocarpine iontophoresis (sweat testing) for cystic fibrosis (CF) newborn screening (NBS).

STUDY DESIGN: Population-based results from follow-up of CF NBS-positive newborns.

RESULTS: Insufficient quantity of sweat is more likely if the sweat test is done too early, but testing is generally successful after 2 weeks of age. Sweat chloride levels drop over the first weeks of life. CF carriers have higher sweat chloride concentrations than non-carriers.

CONCLUSIONS: Sweat testing can be performed effectively after 2 weeks of age for CF NBS-positive newborns. Earlier testing has a higher risk of insufficient sweat for completing testing.

Source

J Pediatr. 2005 Sep;147(3 Suppl):S69-72. Link to article on publisher's site

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DOI
10.1016/j.jpeds.2005.08.015
PubMed ID
16202787
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