Sweat testing infants detected by cystic fibrosis newborn screening
Parad, Richard B. ; Comeau, Anne Marie ; Dorkin, Henry L. ; Dovey, Mark ; Gerstle, Robert ; Martin, Thomas ; O'Sullivan, Brian P.
Citations
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Publication Date
Keywords
Algorithms
Chlorides
Cystic Fibrosis
DNA Mutational Analysis
Decision Trees
Early Diagnosis
False Negative Reactions
False Positive Reactions
Follow-Up Studies
Humans
Infant, Newborn
Iontophoresis
Linear Models
Massachusetts
Muscarinic Agonists
Neonatal Screening
Patient Selection
Pilocarpine
Reference Values
Referral and Consultation
Risk Factors
Sweat
Allergy and Immunology
Pediatrics
Respiratory Tract Diseases
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
OBJECTIVE: Describe and define limitations of early pilocarpine iontophoresis (sweat testing) for cystic fibrosis (CF) newborn screening (NBS).
STUDY DESIGN: Population-based results from follow-up of CF NBS-positive newborns.
RESULTS: Insufficient quantity of sweat is more likely if the sweat test is done too early, but testing is generally successful after 2 weeks of age. Sweat chloride levels drop over the first weeks of life. CF carriers have higher sweat chloride concentrations than non-carriers.
CONCLUSIONS: Sweat testing can be performed effectively after 2 weeks of age for CF NBS-positive newborns. Earlier testing has a higher risk of insufficient sweat for completing testing.
Source
J Pediatr. 2005 Sep;147(3 Suppl):S69-72. Link to article on publisher's site