Oncogenic AKTivation by methylation
Luciano, Amelia K. Guertin, David A.
Luciano, Amelia K.
Guertin, David A.
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2019-02-01
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Abstract
AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.
Source
Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. Link to article on publisher's site
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DOI
10.1038/s41556-019-0275-8
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PubMed ID
30692624