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5-Fluorouracil-associated cardiotoxicity

Freeman, N. J.
Costanza, Mary E.
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Abstract

Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.

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Cancer. 1988 Jan 1;61(1):36-45.

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DOI
10.1002/1097-0142(19880101)61:1<36::AID-CNCR2820610108>3.0.CO;2-6
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3275485
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