Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor
Meng, Xiangjun ; Khanuja, Bhupinder S. ; Ip, Y. Tony
Meng, Xiangjun
Khanuja, Bhupinder S.
Ip, Y. Tony
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Faculty Advisor
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
1999-04-10
Keywords
Androgen-Binding Protein
Animals
Anti-Bacterial Agents
Blotting, Northern
DNA-Binding Proteins
Defensins
Drosophila
*Drosophila Proteins
Exons
Genes, Insect
Insect Proteins
Introns
Membrane Glycoproteins
Models, Genetic
NF-kappa B
Proteins
*Receptors, Cell Surface
*Ribosomal Proteins
Signal Transduction
Time Factors
Toll-Like Receptors
Transcription Factors
Life Sciences
Medicine and Health Sciences
Animals
Anti-Bacterial Agents
Blotting, Northern
DNA-Binding Proteins
Defensins
Drosophila
*Drosophila Proteins
Exons
Genes, Insect
Insect Proteins
Introns
Membrane Glycoproteins
Models, Genetic
NF-kappa B
Proteins
*Receptors, Cell Surface
*Ribosomal Proteins
Signal Transduction
Time Factors
Toll-Like Receptors
Transcription Factors
Life Sciences
Medicine and Health Sciences
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappaB-related factors. Here we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development.
Source
Genes Dev. 1999 Apr 1;13(7):792-7.
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DOI
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PubMed ID
10197979