UnZIPping mechanisms of effector-triggered immunity in animals
Kleino, Anni Silverman, Neal
Kleino, Anni
Silverman, Neal
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UMass Chan Affiliations
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Response or Comment
Publication Date
2012-04-19
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Abstract
The mechanisms by which epithelial cells distinguish pathogens from commensal microbes have long puzzled us. Now, McEwan et al. (2012) and Dunbar et al. (2012), in this issue of Cell Host and Microbe, demonstrate that in C. elegans, microbial toxin-induced inhibition of host cellular functions, especially blockade of protein translation, activates the effector-triggered immune response dependent on the transcription factor ZIP-2.
Source
Cell Host Microbe. 2012 Apr 19;11(4):320-2. doi: 10.1016/j.chom.2012.04.002. Link to article on publisher's site
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DOI
10.1016/j.chom.2012.04.002
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PubMed ID
22520459