Viral defense: it takes two MAVS to Tango
Sharma, Shrutie Fitzgerald, Katherine A
Sharma, Shrutie
Fitzgerald, Katherine A
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UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2010-05-19
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Abstract
To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.
Source
Cell. 2010 May 14;141(4):570-2. Link to article on publisher's site
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DOI
10.1016/j.cell.2010.04.043
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PubMed ID
20478250