LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells
Ethier, Michael F. Madison, John M.
Ethier, Michael F.
Madison, John M.
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Authors
Ethier, Michael F.
Madison, John M.
Madison, John M.
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UMass Chan Affiliations
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Journal Article
Publication Date
2002-07-20
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Abstract
To characterize the effect that a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY294002, has on cytosolic calcium concentrations ([Ca2+]i), bovine airway smooth muscle cells (BASMC) and cultured human bronchial smooth muscle cells (HBSMC) were loaded with fura 2-AM, imaged as single cells and [Ca2+]i measured ratiometrically. LY294002 (50 microM) increased [Ca2+]i by 294+/-76 nM (P
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Cell Calcium. 2002 Jul;32(1):31-8.
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PubMed ID
12127060