The sound of silent RNA in tuberculosis and the lncRNA role on infection
Rocha, Eduardo Fukutani Vinhaes, Caian Leal Araújo-Pereira, Mariana Mota, Tiago Feitosa Gupte, Akshay N Kumar, Nathella Pavan Arriaga, Maria Belen Sterling, Timothy R Babu, Subash Gaikwad, Sanjay
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Vinhaes, Caian Leal
Araújo-Pereira, Mariana
Mota, Tiago Feitosa
Gupte, Akshay N
Kumar, Nathella Pavan
Arriaga, Maria Belen
Sterling, Timothy R
Babu, Subash
Gaikwad, Sanjay
Karyakarte, Rajesh
Mave, Vidya
Kulkarni, Vandana
Paradkar, Mandar
Viswanathan, Vijay
Kornfeld, Hardy
Gupta, Amita
Andrade, Bruno Bezerril
Queiroz, Artur Trancoso Lopo de
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UMass Chan Affiliations
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Abstract
Tuberculosis (TB) is one of the leading causes of death worldwide, and Diabetes Mellitus is one of the major comorbidities (TB/DM) associated with the disease. A total of 103 differentially expressed ncRNAs have been identified in the TB and TB/DM comparisons. A machine learning algorithm was employed to identify the most informative lncRNAs: ADM-DT, LINC02009, LINC02471, SOX2-OT, and GK-AS1. These lncRNAs presented substantial accuracy in classifying TB from HC (AUCs >0.85) and TB/DM from HC (AUCs >0.90) in the other three countries. Genes with significant correlations with the five lncRNAs enriched common pathways in Brazil and India for both TB and TB/DM. This suggests that lncRNAs play an important role in the regulation of genes related to the TB immune response.
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Rocha EF, Vinhaes CL, Araújo-Pereira M, Mota TF, Gupte AN, Kumar NP, Arriaga MB, Sterling TR, Babu S, Gaikwad S, Karyakarte R, Mave V, Kulkarni V, Paradkar M, Viswanathan V, Kornfeld H, Gupta A, Andrade BB, Queiroz ATL; RePORT Brazil; RePORT India Consortia. The sound of silent RNA in tuberculosis and the lncRNA role on infection. iScience. 2023 Dec 8;27(1):108662. doi: 10.1016/j.isci.2023.108662. PMID: 38205253; PMCID: PMC10777062.