Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors
Lehovich, Andre Bruyant, Philippe P. Gifford, Howard C. Schneider, Peter B. Squires, Shane Licho, Robert Gindi, Gene King, Michael A
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Abstract
We compare the image quality of SPECT reconstruction with and without an anatomical prior. Area under the localization-response operating characteristic (LROC) curve is our figure of merit. Simulated Ga-67 citrate images, a SPECT lymph-nodule imaging agent, were generated using the MCAT digital phantom. Reconstructed images were read by human observers. Several reconstruction strategies are compared, including rescaled block iterative (RBI) and maximum-a-posteriori (MAP) with various priors. We find that MAP reconstruction using prior knowledge of organ and lesion boundaries significantly improves lesion-detection performance (p < 0.05). Pseudo-lesion boundaries, regions without increased uptake which are incorrectly treated as prior knowledge of lesion boundaries, do not decrease performance.
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Lehovich A, Bruyant PP, Gifford HC, Schneider PB, Squires S, Licho R, Gindi G, King MA. Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors. IEEE Nucl Sci Symp Conf Rec (1997). 2006;3:1699-1702. doi: 10.1109/NSSMIC.2006.354226. PMID: 19412357; PMCID: PMC2675947. Link to article on publisher's site