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The Evolution of Antisense Oligonucleotide Chemistry - A Personal Journey
Agrawal, Sudhir
Agrawal, Sudhir
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UMass Chan Affiliations
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Journal Article
Publication Date
2021-05-03
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biomedicines_09_00503.pdf
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Abstract
Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.
Source
Agrawal S. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey. Biomedicines. 2021 May 3;9(5):503. doi: 10.3390/biomedicines9050503. PMID: 34063675; PMCID: PMC8147625. Link to article on publisher's site
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DOI
10.3390/biomedicines9050503
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PubMed ID
34063675
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Copyright © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).