Good laboratory practice: preventing introduction of bias at the bench
Macleod, Malcolm R. ; Fisher, Marc ; O'Collins, Victoria ; Sena, Emily S. ; Dirnagl, Ulrich ; Bath, Philip M.W. ; Buchan, Alistair ; van der Worp, H. Bart ; Traystman, Richard ; Minematsu, Kazuo ... show 2 more
Macleod, Malcolm R.
Fisher, Marc
O'Collins, Victoria
Sena, Emily S.
Dirnagl, Ulrich
Bath, Philip M.W.
Buchan, Alistair
van der Worp, H. Bart
Traystman, Richard
Minematsu, Kazuo
Citations
Altmetric:
Student Authors
Faculty Advisor
Academic Program
UMass Chan Affiliations
Document Type
Journal Article
Publication Date
2008-08-16
Subject Area
Embargo Expiration Date
Link to Full Text
Abstract
BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.
CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
Source
Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site
Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1161/STROKEAHA.108.525386
Permanent Link to this Item
PubMed ID
18703798