Publication

Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.
Fisher, Marc
O'Collins, Victoria
Sena, Emily S.
Dirnagl, Ulrich
Bath, Philip M.W.
Buchan, Alistair
van der Worp, H. Bart
Traystman, Richard
Minematsu, Kazuo
... show 2 more
Embargo Expiration Date
Abstract

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Source

Stroke. 2009 Mar;40(3):e50-2. Epub 2008 Aug 14. Link to article on publisher's site

Year of Medical School at Time of Visit
Sponsors
Dates of Travel
DOI
10.1161/STROKEAHA.108.525386
PubMed ID
18703798
Other Identifiers
Notes
Funding and Acknowledgements
Corresponding Author
Related Resources
Related Resources
Repository Citation
Rights
Distribution License